In November 2007, Microchip introduced the PIC32MX family of 32-bit microcontrollers, based on the MIPS32 M4K Core.[12] The device can be programmed using the Microchip MPLAB C Compiler for PIC32 MCUs, a variant of the GCC compiler. The first 18 models currently in production (PIC32MX3xx and PIC32MX4xx) are pin to pin compatible and share the same peripherals set with the PIC24FxxGA0xx family of (16-bit) devices allowing the use of common libraries, software and hardware tools. Today, starting at 28 pin in small QFN packages up to high performance devices with Ethernet, CAN and USB OTG, full family range of mid-range 32-bit microcontrollers are available.

The PIC32 architecture brought a number of new features to Microchip portfolio, including:

• The highest execution speed 80 MIPS (120+[13] Dhrystone MIPS @ 80 MHz)
• The largest flash memory: 512 kB
• One instruction per clock cycle execution
• The first cached processor
• Allows execution from RAM
• Full Speed Host/Dual Role and OTG USB capabilities
• Full JTAG and 2-wire programming and debugging
• Real-time trace

In November 2013, Microchip introduced the PIC32MZ series of microcontrollers, based on the MIPS M14K core. The PIC32MZ series include:

• 252 MHz core speed, 415 DMIPS
• Up to 2 MB Flash and 512KB RAM
• New peripherals including high-speed USB, crypto engine and SQI
• In 2015, Microchip released the PIC32MZ EF family, using the updated MIPS M5150 Warrior M-class processor.[16][17]

In 2017, Microchip introduced the PIC32MZ DA Family, featuring an integrated Graphics Controller, Graphics Processor and 32MB of DDR2 DRAM.

In June 2016, Microchip introduced the PIC32MM family, specialized for low-power and low-cost applications.[20] The PIC32MM features core-independent peripherals, sleep modes down to 500 nA, and 4 x 4 mm packages.[21] The PIC32MM microcontrollers use the MIPS Technologies M4K, a 32-bit MIPS32 processor. They are meant for very low power consumption and limited to 25 MHz. Their key advantage is to support the 16bits instructions of MIPS making program size much more compact (about 40%)

Microchip introduced the PIC32MK family in 2017, specialized for motor control, industrial control, Industrial Internet of Things (IIoT) and multi-channel CAN applications.